The part of Nigel Bigelow was explicitly written for Sir Michael Caine.

Kristin Chenoweth’s part was written specifically for her, because Nicole Kidman very much enjoyed her performance as Glinda in the Broadway musical “Wicked.”

When Aunt Clara’s (Carole Shelley’s) bag drops from the chimney, a whole bunch of doorknobs fall out of it. This is a reference to the original series, in which Aunt Clara “collected” doorknobs.

While the old Columbia lot house from the television show was not used in the movie, the house exterior on the soundstage was labelled “1164.” The commonly accepted address for the Stephens was 1164 Morning Glory Circle, Westport, Connecticut.

After Isabel (Nicole Kidman) tells Jack (Will Ferrell) that she’s a witch, he asks, “Am I gonna get pregnant? Because I cannot get pregnant right now!” Endora cast a spell causing Darrin to feel the same pregnancy symptoms that Samantha felt in an early episode of Bewitched (1964).

In the DVD commentary, Nora Ephron comments that of all Nicole Kidman’s roles, Samantha is the closest to her actual personality.

Writer and director Nora Ephron chose the house that Isabel rents because it once belonged to friends of her parents, and she had visited it often as a child. By sheer coincidence, those friends were Larry Berns and his wife, Sandra Gould—the actress who portrayed the second and more well-known version of Gladys Kravitz. The original Gladys, played by Alice Pearce, passed away after the second season and was succeeded by Gould. Interestingly, Ephron mentioned in the DVD commentary that she didn’t make the connection until after filming had wrapped.

Jim Carrey was approached to play Jack Wyatt/Darrin Stephens, but had to decline because of other commitments.

When Penny Marshall was attached to direct in 1993, her cast was to include Meryl Streep as Samantha Stephens, Barry Humphries in his Dame Edna Everage persona as Endora, Robin Williams as Uncle Arthur, Shelley Winters as Gladys Kravitz, and Jerry Seinfeld and Billy Crystal alternating scenes as Darrin Stephens, in a nod to the role being re-cast midway through the original series’ run.

A picture of the late Elizabeth Montgomery, the original Samantha Stephens from Bewitched (1964), hangs on a mirror in Isabel Bigelow’s dressing room.